FOXO3 and YWHAG

Number of citations of the paper that reports this interaction (PubMedID 15324660)
184

Data Source:
HPRD (in vivo)

		FOXO3	YWHAG
Description		forkhead box O3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Protein-containing Complex	Cytoplasm Cytosol Focal Adhesion Membrane Extracellular Exosome Presynapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Aging Response To Xenobiotic Stimulus Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brain Morphogenesis Response To Fatty Acid Cellular Response To Glucose Stimulus Cellular Response To Corticosterone Stimulus Cellular Response To Hypoxia Response To Dexamethasone Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus Response To Water-immersion Restraint Stress Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Protein Kinase Activity Protein Targeting Signal Transduction Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Cellular Protein Localization Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity
Pathways		Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anxiety/tension (special factor of neuroticism) ( 30867560) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area ( 32963231) Cortical volume ( 32963231) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 32888494 27863252) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Thalamus volume ( 34006833) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)	Multiple sclerosis ( 21654844) Schizophrenia ( 30285260)
Interacting Genes		31 interacting genes: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBIN ESR1 FOXG1 GPR6 HDAC2 IKBKB MAPK1 MAPK6 MDM2 NR1H2 NR1H3 PRDM13 PTPA SGK1 SIM1 SIRT1 SMAD2 SMAD3 SMAD4 TERT TP53 VDR YWHAG YWHAZ	290 interacting genes: ABL1 ABLIM1 ACIN1 AFDN AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5F1A ATP5F1B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L2 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 H3C1 HDAC4 HDAC7 HECTD1 HGF HIVEP2 HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 ITPRID2 JAKMIP1 KANK1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K20 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NHSL2 NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRPF38B PRPF40A PRPF4B PTPN14 PTPN3 PUF60 RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RIPOR2 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPOP SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 STK11 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UBE3A UCP2 UCP3 USP37 USP8 WEE1 WNK1 WWTR1 YAP1 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB21 ZFP36
Entrez ID		2309	7532
HPRD ID		04061	05639
Ensembl ID		ENSG00000118689	ENSG00000170027
Uniprot IDs		O43524	P61981
PDB IDs		2K86 2LQH 2LQI 2UZK 6MNL	2B05 3UZD 4E2E 4J6S 4O46 5D3E 6A5S 6BYJ 6BYL 6BZD 6FEL 6GKF 6GKG 6S9K 6SAD 6Y4K 6Y6B
Enriched GO Terms of Interacting Partners?
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