HECW1 and PRRG4

Number of citations of the paper that reports this interaction (PubMedID 23873930)
7

Data Source:
BioGRID (pull down)

		HECW1	PRRG4
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	proline rich and Gla domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Molecular_function Calcium Ion Binding Protein Binding WW Domain Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Biological_process
Pathways		Degradation of DVL
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	32 interacting genes: ABL2 AOC3 ARHGEF7 BCL10 CYGB ERBB3 ERBB4 FYN GRAP GRB2 HCK HDAC1 HECW1 HLA-C ITCH ITSN1 LYN MAGI1 MAGI2 MAGI3 NEBL NEDD4L OSTF1 PEX13 RBBP8 TEC UBE2K VAV2 VEGFA WWP1 WWTR1 YAP1
Entrez ID		23072	79056
HPRD ID		11385	15187
Ensembl ID		ENSG00000002746	ENSG00000135378
Uniprot IDs		Q76N89	A0A0S2Z5N9 Q9BZD6
PDB IDs		3L4H
Enriched GO Terms of Interacting Partners?
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