SMG1 and SMG8

Number of citations of the paper that reports this interaction (PubMedID 19417104)
105

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		SMG1	SMG8
Description		SMG1 nonsense mediated mRNA decay associated PI3K related kinase	SMG8 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex	Cellular_component Cytosol
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Response To DNA Damage Stimulus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Protein Kinase Activity
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: CDH5 ELOB PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A	3 interacting genes: MKS1 PDZD11 SMG1
Entrez ID		23049	55181
HPRD ID		06123	08551
Ensembl ID		ENSG00000157106	ENSG00000167447
Uniprot IDs		Q96Q15	Q8ND04
PDB IDs		6L53 6L54 6SYT 6Z3R	6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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