ALDOC and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ALDOC	MAP2K3
Description		aldolase, fructose-bisphosphate C	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleoplasm Cytosol Membrane
	Molecular Function	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding	MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Fructose Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation	MAPK Cascade Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction Cellular Senescence
Pathways		Neutrophil degranulation Glycolysis Gluconeogenesis	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs			Fostamatinib
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		9 interacting genes: ANKS1A ATP6V1E1 ERBB2 FMR1 HNF1B LNX1 MAP2K3 PLD2 SQLE	54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		230	5606
HPRD ID		02386	03816
Ensembl ID		ENSG00000109107	ENSG00000034152
Uniprot IDs		A0A024QZ64 P09972	P46734 Q6FI23
PDB IDs		1XFB
Enriched GO Terms of Interacting Partners?
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