MAST1 and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		MAST1	EXOSC1
Description		microtubule associated serine/threonine kinase 1	exosome component 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Peptidyl-serine Phosphorylation Intracellular Signal Transduction	RRNA Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Fostamatinib
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH HSP90AB1 IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 STUB1	31 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC7 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76
Entrez ID		22983	51013
HPRD ID		17469	16223
Ensembl ID		ENSG00000105613	ENSG00000171311
Uniprot IDs		Q9Y2H9	B1AMU3 Q9Y3B2
PDB IDs		2M9X 3PS4	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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