NLRP1 and CASP5

Number of citations of the paper that reports this interaction (PubMedID 12191486)
1786

Data Source:
HPRD (in vitro, in vivo)

		NLRP1	CASP5
Description		NLR family pyrin domain containing 1	caspase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex	Cytoplasm Cytosol NLRP1 Inflammasome Complex
	Molecular Function	Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Self-association Cysteine-type Endopeptidase Activator Activity	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Defense Response To Virus Pyroptosis Self Proteolysis Antiviral Innate Immune Response NLRP1 Inflammasome Complex Assembly	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Substantia Nigra Development Regulation Of Apoptotic Process Regulation Of Inflammatory Response Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway
Pathways		The NLRP1 inflammasome	Pyroptosis
Drugs
Diseases
GWAS		Migraine ( 27322543)
Interacting Genes		9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD	3 interacting genes: MAX NLRP1 PPHLN1
Entrez ID		22861	838
HPRD ID		07364	04048
Ensembl ID		ENSG00000091592	ENSG00000137757
Uniprot IDs		Q9C000	P51878
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6XKK
Enriched GO Terms of Interacting Partners?
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