CLCA4 and AQP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLCA4	AQP2
Description		chloride channel accessory 4	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Metalloendopeptidase Activity Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Metal Ion Binding	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Proteolysis Chloride Transport Ion Transmembrane Transport	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Stimuli-sensing channels	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS		Fasting glucose ( 34074324)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51	61 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 LMAN2L MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		22802	359
HPRD ID		16719	00141
Ensembl ID		ENSG00000016602	ENSG00000167580
Uniprot IDs		Q14CN2	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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