FGF13 and CFLAR

		FGF13	CFLAR
Description		fibroblast growth factor 13	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Neuron Projection	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome
	Molecular Function	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Protein Kinase Activator Activity Transmembrane Transporter Binding Beta-tubulin Binding	Protease Binding Death Receptor Binding Protein Binding Enzyme Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Activation Of Protein Kinase Activity Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Regulation Of Voltage-gated Sodium Channel Activity Response To Odorant	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Cellular Response To Insulin Stimulus Response To Testosterone Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Apoptotic Signaling Pathway Execution Phase Of Apoptosis Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Phase 0 - rapid depolarisation	TRAIL signaling
Drugs
Diseases
GWAS		Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (placlitaxel) ( 23006423)	Rheumatoid arthritis ( 30423114 24390342) Triptolide cytotoxicity ( 26121980)
Interacting Genes		8 interacting genes: APP CFLAR FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A	44 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MYL1 NDUFS1 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 USP8
Entrez ID		2258	8837
HPRD ID		02090	04671
Ensembl ID		ENSG00000129682	ENSG00000003402
Uniprot IDs		A8K1P5 Q92913	A0A024R3Y3 A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		3HBW 4DCK 4JPZ	2N5R 3H11 3H13
Enriched GO Terms of Interacting Partners?
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