FER and PCSK1

		FER	PCSK1
Description		FER tyrosine kinase	proprotein convertase subtilisin/kexin type 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Microtubule Cytoskeleton Lamellipodium Cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding	Serine-type Endopeptidase Activity Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Negative Regulation Of Mast Cell Activation Involved In Immune Response Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process
Pathways		Signaling by SCF-KIT	Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Fostamatinib	Insulin pork
Diseases
GWAS		Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) White blood cell count ( 32888494)	Adult body size ( 32376654) Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Body mass index and fasting glucose (pairwise) ( 33619380) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)
Interacting Genes		23 interacting genes: CALM1 CDH1 CHD1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 GPR15 HSD17B4 IRS1 JAK1 JUP KCTD4 PCSK1 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB	5 interacting genes: FER IAPP PCSK1N PMCH REN
Entrez ID		2241	5122
HPRD ID		01491	01201
Ensembl ID		ENSG00000151422	ENSG00000175426
Uniprot IDs		P16591 Q6PEJ9 W0S0X4 W0S1B5	P29120
PDB IDs		2KK6 6KC4
Enriched GO Terms of Interacting Partners?
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