OARD1 and RAPGEF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OARD1	RAPGEF3
Description		O-acyl-ADP-ribose deacylase 1	Rap guanine nucleotide exchange factor 3
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Site Of DNA Damage	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Purine Nucleoside Binding Protein Binding O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation	Angiogenesis Adaptive Immune Response Signal Transduction CAMP-mediated Signaling Rap Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP Positive Regulation Of Protein Acetylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Histone H3-K9 Acetylation
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease (late onset) ( 30820047) Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)	Bipolar disorder ( 31043756) Body mass index ( 29273807) Body shape index ( 34021172) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		5 interacting genes: APP PICK1 RAPGEF3 RSPH9 TNKS	15 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 SP1 TGFB1 UFSP1 ZRANB1
Entrez ID		221443	10411
HPRD ID		12849	06928
Ensembl ID		ENSG00000124596	ENSG00000079337
Uniprot IDs		A0A024RCY9 C9J5P1 C9JA90 C9JXC3 Q05CR9 Q9Y530	O95398 Q99777
PDB IDs		2EEE 2L8R 2LGR 4J5Q 4J5R 4J5S	6H7E
Enriched GO Terms of Interacting Partners?
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