FCGR2A and CSGALNACT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FCGR2A	CSGALNACT2
Description		Fc fragment of IgG receptor IIa	chondroitin sulfate N-acetylgalactosaminyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane	Golgi Membrane Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding	Protein Binding Acetylgalactosaminyltransferase Activity Metal Ion Binding Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity
	Biological Process	Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Proteoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis	Chondroitin sulfate biosynthesis
Drugs		Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 33772158 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)	Blood protein levels ( 30072576 29875488) Central corneal thickness ( 32528159) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 25310821) Multiple sclerosis ( 24076602)
Interacting Genes		37 interacting genes: ACTR2 ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 F5 FAM3B FCER1A FCER1G FCGR2B FCGR3A FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LIMK2 LYN MGST3 MIP NSG1 PIK3R1 SERP2 SHC1 SYK TARDBP TMCO1 UBQLN1 UPK2	20 interacting genes: ARL13B ATP1B4 BSND CLDN2 CREB3L1 CYB5R3 FCGR2A GPR152 HSD17B11 LMNA MFSD14B MUC1 RETREG3 SLC35E3 SSMEM1 SYNE4 SYT1 TMEM143 TMEM52B UBE2I
Entrez ID		2212	55454
HPRD ID		00906	11348
Ensembl ID		ENSG00000143226	ENSG00000169826
Uniprot IDs		P12318	A0A0S2Z5F5 A0A0S2Z5F9 A0A0S2Z5K4 Q8N6G5
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?
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