FCER1G and KCNN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FCER1G	KCNN3
Description		Fc fragment of IgE receptor Ig	potassium calcium-activated channel subfamily N member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding	Inward Rectifier Potassium Channel Activity Calmodulin Binding Small Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-4 Production Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Positive Regulation Of Phagocytosis Cellular Response To Low-density Lipoprotein Particle Stimulus	Ion Transport Potassium Ion Transmembrane Transport
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	Ca2+ activated K+ channels
Drugs		Benzylpenicilloyl polylysine	Procaine Miconazole Trimebutine
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) White blood cell count ( 32888494)	Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416818 29290336 30061737 29892015 20173747 22544366) Bipolar disorder ( 31043756) Birth weight ( 31043758) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 28552196) Incident atrial fibrillation ( 28416818) Interleukin-6 levels ( 33517400) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Prevalent atrial fibrillation ( 28416818) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		93 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 COX8A CYP4F2 DEFB127 DGAT2L6 EBP F5 FA2H FAM209A FAXDC2 FCER1A FCGR2A FCGR2B FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL MIF NCR1 NCR3 NIT1 NRM ORMDL2 PDZD3 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 PTPN5 RUSF1 SEC22B SELP SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 SPRR1A STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	12 interacting genes: APP CALM1 CLCN7 CRABP2 EMD ERMP1 FCER1G HAX1 ILF2 NAPB SLC27A3 UBAP2L
Entrez ID		2207	3782
HPRD ID		00916	04283
Ensembl ID		ENSG00000158869	ENSG00000143603
Uniprot IDs		P30273	A0A087WYJ0 Q9UGI6
PDB IDs
Enriched GO Terms of Interacting Partners?
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