FBN2 and TRIM24

		FBN2	TRIM24
Description		fibrillin 2	tripartite motif containing 24
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Euchromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Ubiquitin Protein Ligase Activity Lysine-acetylated Histone Binding
	Biological Process	Anatomical Structure Morphogenesis Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation	Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Brain morphology (MOSTest) ( 32665545) Breastfeeding duration ( 25475840) Central corneal thickness ( 32528159) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 32771030) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960) Waist circumference adjusted for body mass index ( 34021172)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)
Interacting Genes		22 interacting genes: CMBL CSF2 DPYSL5 DUSP5 ELN FBN1 FDPS ITGA2 LTBP1 MATN2 MFAP2 MFAP5 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SMAD2 SNRPB TRIM24 UBE2B	55 interacting genes: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 CREBBP ESR1 ESR2 FBN2 FOSL1 GTF2E1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HNF4A HSPA1A HSPB1 IFT88 MRPS33 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRAF3 TRIM28 TRIM33 TRIM8 UBE2D1 UBE2I UBE2U VDR ZNF10
Entrez ID		2201	8805
HPRD ID		00416	04556
Ensembl ID		ENSG00000138829	ENSG00000122779
Uniprot IDs		P35556	A0A024R784 O15164
PDB IDs			2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V
Enriched GO Terms of Interacting Partners?
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