ENKUR and PIK3R2

Number of citations of the paper that reports this interaction (PubMedID 15385169)
22

Data Source:
BioGRID (pull down)

		ENKUR	PIK3R2
Description		enkurin, TRPC channel interacting protein	phosphoinositide-3-kinase regulatory subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Sperm Principal Piece 9+0 Motile Cilium 9+2 Motile Cilium	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding Calmodulin Binding SH3 Domain Binding	Phosphotyrosine Residue Binding Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Flagellated Sperm Motility Establishment Of Left/right Asymmetry	Cellular Glucose Homeostasis Insulin Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Protein Transport Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylinositol Phosphate Biosynthetic Process
Pathways			PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs			Isoprenaline SF1126
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)
Interacting Genes		7 interacting genes: CFAP45 GPR158 LRRK1 LRRK2 PIK3R1 PIK3R2 TRPC5	59 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		219670	5296
HPRD ID		12583	04404
Ensembl ID		ENSG00000151023	ENSG00000105647
Uniprot IDs		A0A087WUX1 Q8TC29	O00459
PDB IDs			2KT1 2XS6 3MTT 3O5Z 6OX7 6U28
Enriched GO Terms of Interacting Partners?
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