FAT1 and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 28129444)
3

Data Source:
BioGRID (two hybrid)

		FAT1	NOXA1
Description		FAT atypical cadherin 1	NADPH oxidase activator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Apical Plasma Membrane Lamellipodium Filopodium Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol NADPH Oxidase Complex
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding
	Biological Process	Lens Development In Camera-type Eye Epithelial Cell Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Cell Migration Cell-cell Adhesion	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Catalytic Activity Regulation Of Respiratory Burst
Pathways			RHO GTPases Activate NADPH Oxidases CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Carotid plaque burden ( 28282560) Chronotype ( 26955885) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Major depressive disorder ( 29317602) Medication use (calcium channel blockers) ( 31015401) Morning vs. evening chronotype ( 26955885) Obesity ( 21552555) PR interval ( 30046033 32439900) Triglyceride levels in HIV infection ( 33109212) Urinary albumin-to-creatinine ratio ( 31630189)	Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		12 interacting genes: CLK1 ENAH HOMER1 HOMER3 IGLL1 MT-ND1 NOXA1 SORBS2 TRAF4 TRIM14 UBC VASP	57 interacting genes: ANKRD55 C19orf54 C9orf24 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620
Entrez ID		2195	10811
HPRD ID		02986	17644
Ensembl ID		ENSG00000083857	ENSG00000188747
Uniprot IDs		Q14517	Q86UR1
PDB IDs
Enriched GO Terms of Interacting Partners?
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