FANCA and NAMPT

Number of citations of the paper that reports this interaction (PubMedID 14499622)
15

Data Source:
BioGRID (two hybrid)

		FANCA	NAMPT
Description		FA complementation group A	nicotinamide phosphoribosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex	Cytosol Plasma Membrane Nuclear Speck Cell Junction Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Population Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway	Microglial Cell Activation Signal Transduction Cell-cell Signaling Female Pregnancy Aging Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Negative Regulation Of Autophagy Response To Organic Cyclic Compound Regulation Of Lung Blood Pressure Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development Neuron Death Cellular Response To Ionizing Radiation Cellular Response To Oxygen-glucose Deprivation Cellular Response To Amyloid-beta Response To D-galactose Negative Regulation Of Cellular Senescence
Pathways		Fanconi Anemia Pathway	BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinamide salvaging
Drugs			GMX1777 Daporinad
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)	Grapefruit juice consumption ( 31046077)
Interacting Genes		47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	7 interacting genes: ADORA2A AKT2 FANCA GGT1 LOX OGT USP49
Entrez ID		2175	10135
HPRD ID		06186	09938
Ensembl ID		ENSG00000187741	ENSG00000105835
Uniprot IDs		O15360	A0A024R718 P43490
PDB IDs			2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB 6TA0 6TA2 6TAC
Enriched GO Terms of Interacting Partners?
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