F5 and CTSG

Number of citations of the paper that reports this interaction (PubMedID 9718313)
15

Data Source:
HPRD (in vitro)

		F5	CTSG
Description		coagulation factor V	cathepsin G
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Blood Coagulation Blood Circulation	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Purinergic Nucleotide Receptor Signaling Pathway Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs		Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex	Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Iron status biomarkers (ferritin levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Ischemic stroke ( 26732560) Macrovascular complications in type 2 diabetes ( 33430853) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 25631615 31798171) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 33592630 21980494 23650146 25772935 32232851 28373160 31420334 22672568 31676865) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		13 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 FCER1G FCGR2A MMRN1 PROC PROS1 SERPINA3 SRPK2	31 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA HTR2A IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		2153	1511
HPRD ID		01964	00289
Ensembl ID		ENSG00000198734	ENSG00000100448
Uniprot IDs		P12259	P08311
PDB IDs		1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C	1AU8 1CGH 1KYN 1T32 6VTM
Enriched GO Terms of Interacting Partners?
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