ABCD1 and PEX19

Number of citations of the paper that reports this interaction (PubMedID 10777694)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ABCD1	PEX19
Description		ATP binding cassette subfamily D member 1	peroxisomal biogenesis factor 19
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Brush Border Membrane Protein-containing Complex
	Molecular Function	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ABC-type Fatty-acyl-CoA Transporter Activity ATP Hydrolysis Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Acyl-CoA Hydrolase Activity	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-terminus Binding ATPase Binding Protein Carrier Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Chaperone-mediated Protein Folding Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding
Pathways		ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 34059833)
Interacting Genes		6 interacting genes: ABCD2 ABCD3 ATP6AP1 PEX19 RPSA SLC27A2	39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 MFSD5 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2
Entrez ID		215	5824
HPRD ID		02300	02610
Ensembl ID		ENSG00000101986	ENSG00000162735
Uniprot IDs		P33897	A0A0S2Z497 P40855
PDB IDs			2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?
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