ETV5 and CYP3A5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ETV5	CYP3A5
Description		ETS variant transcription factor 5	cytochrome P450 family 3 subfamily A member 5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxygen Binding Heme Binding Testosterone 6-beta-hydroxylase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Glial Cell Proliferation	Lipid Hydroxylation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Aflatoxin Metabolic Process Oxidative Demethylation
Pathways			Xenobiotics Aflatoxin activation and detoxification
Drugs			Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 29381148 23563607 19079260 26961502 28892062 25673413 20935630 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31152163 31451708 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) Hip circumference ( 25673412) Hyperuricemia ( 29124443) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 27182965 21102462) Obesity ( 23563607) Platelet distribution width ( 32888494) Serum uric acid levels ( 29124443) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference ( 25673412) Weight ( 19079260)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Platelet count ( 29403010) Serum metabolite levels ( 33031748 23093944) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: AMH AP2M1 APP AR BRCA1 CCR5 CISH CYP3A5 DHRS7 GRAP2 HOXD9 MFHAS1 SEZ6L2 SLC22A2	3 interacting genes: ATOH8 ETV5 RDH13
Entrez ID		2119	1577
HPRD ID		09035	05617
Ensembl ID		ENSG00000244405	ENSG00000106258
Uniprot IDs		P41161	B7Z3P6 P20815
PDB IDs		4UNO 5ILV	5VEU
Enriched GO Terms of Interacting Partners?
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