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ERCC6 and TPR
Number of citations of the paper that reports this interaction (PubMedID
31722399
)
7
Data Source:
BioGRID
(pull down)
ERCC6
TPR
Description
ERCC excision repair 6, chromatin remodeling factor
translocated promoter region, nuclear basket protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Site Of DNA Damage
Kinetochore
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytoplasmic Dynein Complex
Extrinsic Component Of Membrane
Nuclear Membrane
Nuclear Periphery
Nuclear Inclusion Body
Nuclear Pore Nuclear Basket
Mitotic Spindle
Molecular Function
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
ATP-dependent Activity, Acting On DNA
ATP Hydrolysis Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
ATP-dependent Chromatin Remodeler Activity
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
Tubulin Binding
Structural Constituent Of Nuclear Pore
Heat Shock Protein Binding
Protein Homodimerization Activity
Protein-membrane Adaptor Activity
Mitogen-activated Protein Kinase Binding
Dynein Complex Binding
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint Signaling
Response To Superoxide
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Chromatin Remodeling
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Response To Oxidative Stress
JNK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Neurogenesis
Neuron Differentiation
Neuron Projection Development
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Protein Tyrosine Kinase Activity
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Transcription By RNA Polymerase II
RNA Import Into Nucleus
RNA Export From Nucleus
MRNA Export From Nucleus
Protein Import Into Nucleus
Protein Export From Nucleus
Nuclear Pore Organization
Mitotic Spindle Assembly Checkpoint Signaling
Regulation Of MRNA Export From Nucleus
Regulation Of Mitotic Sister Chromatid Separation
Positive Regulation Of Heterochromatin Assembly
Regulation Of Protein Stability
MRNA Export From Nucleus In Response To Heat Stress
Regulation Of Protein Localization
Cellular Response To Heat
Cellular Response To Interferon-alpha
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Nuclear Matrix Organization
Negative Regulation Of Translational Initiation
Regulation Of Protein Export From Nucleus
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of RNA Export From Nucleus
Nuclear Pore Complex Assembly
Cell Division
Response To Epidermal Growth Factor
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Intracellular Protein Transport
Regulation Of Mitotic Spindle Assembly
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Interacting Genes
117 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP4
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
14 interacting genes:
APC
ERCC6
HTT
IFI16
MAD1L1
MAP3K4
MAPK1
MDM2
NUP153
NUP98
SHC1
SUMO2
TNFSF4
YWHAQ
Entrez ID
2074
7175
HPRD ID
00596
08927
Ensembl ID
ENSG00000225830
ENSG00000047410
Uniprot IDs
A8K4Q3
P0DP91
Q03468
Q59FF6
P12270
PDB IDs
4CVO
6A6I
5TO5
5TO6
5TO7
5TVB
Enriched GO Terms of Interacting Partners
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