EPHB3 and RYK

Number of citations of the paper that reports this interaction (PubMedID 11956217)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EPHB3	RYK
Description		EPH receptor B3	receptor like tyrosine kinase
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GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuron Projection Receptor Complex	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Angiogenesis Urogenital System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Axonal Fasciculation Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axonogenesis Axon Guidance Synapse Assembly Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Cell Proliferation In Midbrain Positive Regulation Of Kinase Activity Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Commissural Neuron Axon Guidance Planar Cell Polarity Pathway Involved In Axon Guidance Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	TCF dependent signaling in response to WNT PCP/CE pathway
Drugs
Diseases
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		14 interacting genes: AFDN CRK EFNB3 ERBB2 FBXO7 FYN GBE1 HPCAL1 HSF2BP LNX1 NFRKB RASA1 RNF186 RYK	8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A
Entrez ID		2049	6259
HPRD ID		03502	02751
Ensembl ID		ENSG00000182580	ENSG00000163785
Uniprot IDs		P54753	P34925 Q59FQ5 Q8WTZ8
PDB IDs		3P1I 3ZFY 5L6O 5L6P	6TUA
Enriched GO Terms of Interacting Partners?
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