EPHA1 and SMURF2

Number of citations of the paper that reports this interaction (PubMedID 15761153)
269

Data Source:
HPRD (in vivo)

		EPHA1	SMURF2
Description		EPH receptor A1	SMAD specific E3 ubiquitin protein ligase 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft
	Molecular Function	Fibronectin Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Activation Of GTPase Activity	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488 28240269) Family history of Alzheimer's disease ( 30617256) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE	91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FOXJ1 FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SIRT1 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44
Entrez ID		2041	64750
HPRD ID		01554	06901
Ensembl ID		ENSG00000146904	ENSG00000108854
Uniprot IDs		P21709	Q96DE7 Q9HAU4
PDB IDs		2K1K 2K1L 3HIL 3KKA	1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?