ENPEP and CCK

Number of citations of the paper that reports this interaction (PubMedID 8804068)
17

Data Source:
HPRD (in vivo, in vitro)

		ENPEP	CCK
Description		glutamyl aminopeptidase	cholecystokinin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border External Side Of Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Extracellular Exosome	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon
	Molecular Function	Aminopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity	Hormone Activity Neuropeptide Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Angiogenesis Angiotensin Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Signal Transduction Cell-cell Signaling Regulation Of Blood Pressure Cell Population Proliferation Cell Migration Glomerulus Development Peptide Catabolic Process	Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Digestion Memory Positive Regulation Of Cell Population Proliferation Visual Learning Positive Regulation Of Glutamate Secretion Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Appetite Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Eating Behavior Positive Regulation Of Sensory Perception Of Pain Negative Regulation Of Behavioral Fear Response Positive Regulation Of Behavioral Fear Response
Pathways		Metabolism of Angiotensinogen to Angiotensins	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Glutamic acid	Camostat
Diseases
GWAS		Atrial fibrillation/atrial flutter ( 17603472) Blood pressure ( 21572416) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension ( 30487518) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Iris heterochromicity ( 29109912) Lung cancer ( 28604730) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolic traits ( 21886157) Pursuit maintenance gain ( 29064472) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Systolic blood pressure ( 28135244 30487518 30578418)	Adult body size ( 32376654) Body mass index ( 24348519 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: AGT CCK	7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
Entrez ID		2028	885
HPRD ID		08848	00321
Ensembl ID		ENSG00000138792	ENSG00000187094
Uniprot IDs		Q07075	P06307 Q6FG82
PDB IDs		4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD
Enriched GO Terms of Interacting Partners?
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