ENO2 and SIGIRR

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ENO2	SIGIRR
Description		enolase 2	single Ig and TIR domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Membrane Perikaryon Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding	NAD+ Nucleosidase Activity Protein Binding
	Biological Process	Glycolytic Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity
Pathways		Glycolysis Gluconeogenesis	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
Drugs		2-Phosphoglycolic Acid
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494)
Interacting Genes		27 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 CD27 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C UBE3A	9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID		2026	59307
HPRD ID		00573	12018
Ensembl ID		ENSG00000111674	ENSG00000185187
Uniprot IDs		P09104 Q6FHV6	C9JFX4 Q6IA17
PDB IDs		1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ
Enriched GO Terms of Interacting Partners?
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