CTTN and CD5

		CTTN	CD5
Description		cortactin	CD5 molecule
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GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Lamellipodium Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Dendritic Spine Intracellular Membrane-bounded Organelle Mitotic Spindle Midzone	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding	Scavenger Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Endocytosis Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 24076602 21833088) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		44 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CD5 CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 RPL9 SDC3 SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 WASL WIPF1	27 interacting genes: CAMK2D CAPN1 CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CFL1 CSNK2A1 CTTN DNASE1L2 DYNLT3 FYN HNRNPU LCK MX1 PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70 ZNHIT2
Entrez ID		2017	921
HPRD ID		01268	01078
Ensembl ID		ENSG00000085733	ENSG00000110448
Uniprot IDs		A0A024R5M3 Q14247 Q53HG7	P06127
PDB IDs		1X69 2D1X	2JA4 2JOP 2JP0 2OTT
Enriched GO Terms of Interacting Partners?
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