TRIM65 and UBE2Z

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		TRIM65	UBE2Z
Description		tripartite motif containing 65	ubiquitin conjugating enzyme E2 Z
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytosol
	Molecular Function	Zinc Ion Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Positive Regulation Of Autophagy	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)
Interacting Genes		14 interacting genes: ANAPC11 DDX58 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2N UBE2U UBE2Z UBE3A VCAM1	39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		201292	65264
HPRD ID		15569	08589
Ensembl ID		ENSG00000141569	ENSG00000159202
Uniprot IDs		Q6PJ69	Q9H832
PDB IDs		7JL0 7JL2 7JL4	5A4P
Enriched GO Terms of Interacting Partners?
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