FLCN and NANS

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		FLCN	NANS
Description		folliculin	N-acetylneuraminate synthase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone Mitotic Spindle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein-containing Complex Binding	N-acylneuraminate Cytidylyltransferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Regulation Of Cytokinesis Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process	CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process Glycosylation
Pathways		Amino acids regulate mTORC1	Sialic acid metabolism
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)	Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		11 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS TMEFF1 TSTD2	20 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ RFX3 SRC STK11 TLR2
Entrez ID		201163	54187
HPRD ID		06278	07285
Ensembl ID		ENSG00000154803	ENSG00000095380
Uniprot IDs		A0A0S2Z5Y7 Q8NFG4	Q9NR45
PDB IDs		3V42 6NZD 6ULG	1WVO
Enriched GO Terms of Interacting Partners?
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