MARK2 and OSBP

		MARK2	OSBP
Description		microtubule affinity regulating kinase 2	oxysterol binding protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding Oxysterol Binding Sterol Transporter Activity Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Sterol Transfer Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	Bile Acid Biosynthetic Process Sterol Transport Intracellular Cholesterol Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Intermembrane Lipid Transfer Positive Regulation Of Secretory Granule Organization
Pathways			Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		42 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 FLRT1 GAB1 GSK3B HDAC7 INCENP ISOC1 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L NUAK1 NXF1 OSBP PARD3B PARD6A PINK1 PKD1 PLAAT3 PPP2R5B PRKCE PTPRD RAB11FIP2 RNF41 RPA2 RPS6KB1 SCGB1A1 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ	3 interacting genes: CSNK2A1 MARK2 VAPA
Entrez ID		2011	5007
HPRD ID		02753	01327
Ensembl ID		ENSG00000072518	ENSG00000110048
Uniprot IDs		A0A140VJP1 A8K2S4 E7ETY4 Q7KZI7	P22059
PDB IDs		3IEC 5EAK 5KZ7 5KZ8	2RR3
Enriched GO Terms of Interacting Partners?
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