EIF4EBP2 and EIF4E

Number of citations of the paper that reports this interaction (PubMedID 7935836)
414

Data Source:
HPRD (in vivo, in vitro)

		EIF4EBP2	EIF4E
Description		eukaryotic translation initiation factor 4E binding protein 2	eukaryotic translation initiation factor 4E
Image
GO Annotations	Cellular Component	Cytoplasm Postsynapse	P-body Nucleus Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding DNA-binding Transcription Factor Binding
	Biological Process	Translation Memory Insulin Receptor Signaling Pathway CAMP-mediated Signaling TOR Signaling Social Behavior Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Lung Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways			ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Pulse pressure ( 33230300) Sensation seeking ( 30718321)
Interacting Genes		6 interacting genes: CDK4 EIF4E FHL3 LSM3 MTOR RPTOR	27 interacting genes: APP BIRC2 BRWD1 CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG PTEN TDO2 TRIM27 UBXN11
Entrez ID		1979	1977
HPRD ID		03747	00591
Ensembl ID		ENSG00000148730	ENSG00000151247
Uniprot IDs		A0A024QZM3 Q13542	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs		2MX4 3AM7	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML
Enriched GO Terms of Interacting Partners?
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