EGF and DUSP3

Number of citations of the paper that reports this interaction (PubMedID 1281549)
38

Data Source:
HPRD (in vitro)

		EGF	DUSP3
Description		epidermal growth factor	dual specificity phosphatase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Lumen Extracellular Exosome	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Receptor Internalization Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Via MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Receptor Signaling Pathway Via JAK-STAT Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Secretion Positive Regulation Of Protein Kinase B Signaling Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Epithelial Tube Formation Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		Platelet degranulation Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants	ERKs are inactivated
Drugs		Sucralfate Alpha-Aminobutyric Acid Cholecystokinin Tesevatinib
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Blood protein levels ( 30072576 29875488) Glycated hemoglobin levels ( 34059833) Hair morphology ( 19896111) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 29403010 33545615 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Spleen volume ( 34128465) Waist-to-hip ratio adjusted for BMI ( 28552196)	Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) High density lipoprotein cholesterol levels ( 33339817) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		14 interacting genes: ADAM12 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 GRK2 LMNA MGST1 NRG1 PIK3R1 PIK3R2 VTN	15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		1950	1845
HPRD ID		00578	02553
Ensembl ID		ENSG00000138798	ENSG00000108861
Uniprot IDs		P01133	P51452
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP	1J4X 1VHR 3F81
Enriched GO Terms of Interacting Partners?
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