EFNA5 and EPHA4

Number of citations of the paper that reports this interaction (PubMedID 8755474)
231

Data Source:
HPRD (in vitro)

		EFNA5	EPHA4
Description		ephrin A5	EPH receptor A4
Image
GO Annotations	Cellular Component	Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Cell Surface Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Neuron Projection Dendritic Spine Dendritic Shaft Perikaryon Receptor Complex Axon Terminus Axonal Growth Cone Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding	Amyloid-beta Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Negative Regulation Of Cell Migration Positive Regulation Of Kinase Activity Adherens Junction Organization Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cell Adhesion Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Alzheimer's disease biomarkers ( 23419831) Aspartate aminotransferase levels ( 34315874) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)
Interacting Genes		39 interacting genes: ACKR2 AQP2 AQP6 BEST2 CD53 CLDN5 CYB561 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 FFAR3 GJB1 GPR151 GPR152 GPR161 GPR42 GRIP1 HERPUD2 HIBADH KASH5 MS4A3 RHCG SGPL1 SLC10A2 SLC13A4 SLC16A2 SLC35C2 SRC SSMEM1 TM4SF18 TMEM237 TRHR TSPO2 YIPF6	18 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 ETS1 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC TNS3
Entrez ID		1946	2043
HPRD ID		03324	03719
Ensembl ID		ENSG00000184349	ENSG00000116106
Uniprot IDs		D6RDV5 P52803	A1MA61 P54764
PDB IDs		2X11 3MX0 4BK5 4BKA 4L0P 4M4R	2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2
Enriched GO Terms of Interacting Partners?
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