ECE1 and CFLAR

		ECE1	CFLAR
Description		endothelin converting enzyme 1	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Peptide Hormone Binding Protein Homodimerization Activity	Protease Binding Death Receptor Binding Protein Binding Enzyme Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin G Protein-coupled Receptor Signaling Pathway Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Cellular Response To Insulin Stimulus Response To Testosterone Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Apoptotic Signaling Pathway Execution Phase Of Apoptosis Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Peptide ligand-binding receptors	TRAIL signaling
Drugs		5-(2-hydroxyethyl)nonane-1,9-diol
Diseases
GWAS		Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)	Rheumatoid arthritis ( 30423114 24390342) Triptolide cytotoxicity ( 26121980)
Interacting Genes		15 interacting genes: AGT CALCA CFLAR CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC	44 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MYL1 NDUFS1 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 USP8
Entrez ID		1889	8837
HPRD ID		02690	04671
Ensembl ID		ENSG00000117298	ENSG00000003402
Uniprot IDs		A0A024RAB0 A0A024RAB2 A1PUP8 P42892	A0A024R3Y3 A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		3DWB	2N5R 3H11 3H13
Enriched GO Terms of Interacting Partners?
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