E2F6 and TFDP2

Number of citations of the paper that reports this interaction (PubMedID 9501179)
64

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		E2F6	TFDP2
Description		E2F transcription factor 6	transcription factor Dp-2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Mitotic Spindle RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Cell Cycle Heart Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		G1/S-Specific Transcription Transcriptional Regulation by E2F6	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria G0 and Early G1 Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 20383146) Congenital left-sided heart lesions ( 33201861) Cortical surface area (global PC1) ( 32198502) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hip circumference ( 28552196) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728 26503584) Total hippocampal volume ( 30279459) Urate levels ( 31578528)
Interacting Genes		29 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 DRD2 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11	6 interacting genes: E2F1 E2F2 E2F3 E2F4 E2F6 YWHAE
Entrez ID		1876	7029
HPRD ID		04251	03696
Ensembl ID		ENSG00000169016	ENSG00000114126
Uniprot IDs		A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5	Q14188
PDB IDs			1CF7
Enriched GO Terms of Interacting Partners?
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