JAG1 and MTDH

Number of citations of the paper that reports this interaction (PubMedID 22199357)
31

Data Source:
BioGRID (unspecified method)

		JAG1	MTDH
Description		jagged canonical Notch ligand 1	metadherin
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane	Fibrillar Center Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Notch Signaling Pathway Nervous System Development Negative Regulation Of Cell-cell Adhesion Hemopoiesis Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Notch Signaling Involved In Heart Development Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Glomerular Visceral Epithelial Cell Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Bicellular Tight Junction Assembly
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling RAC1 GTPase cycle RAC3 GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Bone mineral density ( 20096396) Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618447 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Eosinophil counts ( 32888494) Frontotemporal dementia (age at onset) ( 29724592) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density ( 29499414 22504420) Lymphocyte counts ( 32888494) Migraine ( 27322543) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Red blood cell count ( 32888494) Systolic blood pressure ( 28135244 27841878 21909115 28739976 27618452 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 28828242) Urate levels ( 31578528) Urinary bladder cancer ( 24861552)	Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 32888494 27863252 28957414) Sweet taste preference ( 32572145)
Interacting Genes		10 interacting genes: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 SH2D4A THBS1	175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CENPJ CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 GHDC GLG1 GRID1 HACE1 HERC5 HP1BP3 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PDCD11 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC22A18AS SLC38A4 SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 VIM WDFY2 WNK2 ZNF559 ZXDC
Entrez ID		182	92140
HPRD ID		03562	17459
Ensembl ID		ENSG00000101384	ENSG00000147649
Uniprot IDs		P78504 Q99740	A0A024R9D2 Q86UE4
PDB IDs		2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1	4QMG
Enriched GO Terms of Interacting Partners?
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