DRD1 and HRH3

Number of citations of the paper that reports this interaction (PubMedID 19413572)
50

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DRD1	HRH3
Description		dopamine receptor D1	histamine receptor H3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendritic Spine Ciliary Membrane Non-motile Cilium	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Presynapse
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Synapse Assembly Mating Behavior Adult Walking Behavior Visual Learning Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Transmission Of Nerve Impulse Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Vasodilation Dopamine Metabolic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Dopamine	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Negative Regulation Of Glutamate Secretion Regulation Of Norepinephrine Secretion Negative Regulation Of Serotonin Secretion Cognition G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Histamine receptors
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil	Olopatadine Aripiprazole OBE101 Histamine Betahistine Pitolisant
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Prostate cancer ( 23535732)
Interacting Genes		17 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DLG4 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 PDCD6IP PRKACA VPS35	3 interacting genes: ADORA2A DRD1 DRD2
Entrez ID		1812	11255
HPRD ID		00538	05162
Ensembl ID		ENSG00000184845	ENSG00000101180
Uniprot IDs		P21728	Q9Y5N1
PDB IDs		1OZ5 7CKW 7CKX 7CKY 7CKZ 7CRH 7JV5 7JVP 7JVQ 7LJC 7LJD
Enriched GO Terms of Interacting Partners?
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