Description |
dipeptidyl peptidase 4 |
gastrin releasing peptide |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- Atorvastatin
- Sitagliptin
- 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One
- 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine
- (2s)-Pyrrolidin-2-Ylmethylamine
- 4-Iodo-L-phenylalanine
- Diisopropylphosphono Group
- 1-(1-phenylcyclopentyl)methylamine
- (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
- Vildagliptin
- PSN9301
- AMG-222
- Bisegliptin
- Alogliptin
- Saxagliptin
- (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
- N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE
- (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
- (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine
- (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine
- (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine
- (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE
- (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE
- (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
- (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE
- (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE
- (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE
- 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
- (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
- 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile
- 4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
- METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE
- (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
- 1-biphenyl-2-ylmethanamine
- (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE
- (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
- N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE
- (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE
- (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE
- 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE
- ABT-341
- (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
- (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE
- Gosogliptin
- N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide
- (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
- 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
- 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE
- 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE
- 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE
- 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE
- Linagliptin
- Dutogliptin
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Diseases |
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GWAS |
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- Adult body size ( 32376654)
- BMI (adjusted for smoking behaviour) ( 28443625)
- BMI in non-smokers ( 28443625)
- Body mass index ( 25673413)
- Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
- Medication use (drugs used in diabetes) ( 31015401)
- Pancreas volume ( 34128465)
- Pancreatic cancer ( 29422604 26098869)
- Pancreatic ductal adenocarcinoma ( 30541042)
- Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
- Type 2 diabetes ( 30297969)
- Venous thromboembolism ( 32232851)
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Interacting Genes |
16 interacting genes:
ADA
CCL11
CCL22
CCL3L1
CCL5
CD4
CPAMD8
CXCL10
CXCL11
CXCL12
CXCL9
CXCR4
DKK1
FAP
GRP
PTPRC
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5 interacting genes:
ALX1
DPP4
GRPR
MEP1A
MEP1B
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Entrez ID |
1803 |
2922 |
HPRD ID |
02187 |
08845 |
Ensembl ID |
ENSG00000197635
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ENSG00000134443
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Uniprot IDs |
P27487
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A0A140VJM7
P07492
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PDB IDs |
1J2E
1N1M
1NU6
1NU8
1PFQ
1R9M
1R9N
1RWQ
1TK3
1TKR
1U8E
1W1I
1WCY
1X70
2AJL
2BGN
2BGR
2BUB
2FJP
2G5P
2G5T
2G63
2HHA
2I03
2I78
2IIT
2IIV
2JID
2OAG
2OGZ
2OLE
2ONC
2OPH
2OQI
2OQV
2P8S
2QJR
2QKY
2QOE
2QT9
2QTB
2RGU
2RIP
3BJM
3C43
3C45
3CCB
3CCC
3D4L
3EIO
3F8S
3G0B
3G0C
3G0D
3G0G
3H0C
3HAB
3HAC
3KWF
3KWJ
3NOX
3O95
3O9V
3OC0
3OPM
3Q0T
3Q8W
3QBJ
3SWW
3SX4
3VJK
3VJL
3VJM
3W2T
3WQH
4A5S
4DSA
4DSZ
4DTC
4G1F
4J3J
4JH0
4KR0
4L72
4LKO
4N8D
4N8E
4PNZ
4PV7
4QZV
5I7U
5ISM
5J3J
5KBY
5T4B
5T4E
5T4F
5T4H
5Y7H
5Y7J
5Y7K
5ZID
6B1E
6B1O
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2N0B
2N0C
2N0D
2N0E
2N0F
2N0G
2N0H
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Enriched GO Terms of Interacting Partners? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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