DOCK2 and KRTAP9-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DOCK2	KRTAP9-3
Description		dedicator of cytokinesis 2	keratin associated protein 9-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome	Cytosol Keratin Filament
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding T Cell Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nef and signal transduction Neutrophil degranulation RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production	Keratinization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Coronary artery aneurysm in Kawasaki disease ( 33772158) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		49 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CRKL CYSRT1 ELMO1 GNAL GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1	127 interacting genes: ADAMTSL4 ANKS1A ATN1 C9orf24 CARD10 CATSPER1 CCER1 CELF5 CERCAM CHRD CHRNG CNNM3 COL8A1 CRCT1 CREB5 CRH CYSRT1 DCDC2 DMRT3 DOCK2 ECM1 FAM124B FBXO34 FBXW5 GET4 GLRX3 GNE HOXA1 HOXA9 INCA1 ITGB4 JOSD1 KLHL38 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 MAPKBP1 MEOX2 NBPF19 NECTIN3 NOTCH2NLA NPDC1 NR1D2 NR4A3 NTM NUFIP2 OTX1 PAX5 PAX6 PHLDA1 POU4F2 PRKAB2 PTPMT1 PVR RAMP3 RGS20 SH3GLB2 SHFL SLC13A5 SLC23A1 SLC25A18 SMCP SPRY1 TFAP2D TOX3 TRIM42 TSPAN4 UNC119 VASN VGLL3 WNT11 YY1 ZNF414 ZNF439 ZNF440 ZNF497 ZNF575
Entrez ID		1794	83900
HPRD ID		09121	13950
Ensembl ID		ENSG00000134516	ENSG00000204873
Uniprot IDs		Q5XG91 Q92608	Q9BYQ3
PDB IDs		2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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