DLG2 and CNKSR2

Number of citations of the paper that reports this interaction (PubMedID 16637659)
29

Data Source:
HPRD (in vitro)

		DLG2	CNKSR2
Description		discs large MAGUK scaffold protein 2	connector enhancer of kinase suppressor of Ras 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Axon Cytoplasm	Cytoplasm Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding Kinase Binding	Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Chemical Synaptic Transmission Embryo Development Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport	Regulation Of Signal Transduction Intracellular Signal Transduction Postsynapse Organization
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 32201043 28892059 28011712 17052657 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Schizophrenia x sex interaction ( 34099189) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)	Bipolar disorder ( 31043756) Educational attainment (years of education) ( 30038396) Schizophrenia ( 25056061) Type 2 diabetes ( 30718926)
Interacting Genes		53 interacting genes: ABCA1 ALK AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VTN WNT3A	13 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK
Entrez ID		1740	22866
HPRD ID		04663	06473
Ensembl ID		ENSG00000150672	ENSG00000149970
Uniprot IDs		B7Z2T4 Q15700	A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2
PDB IDs		2BYG 2HE2	2EAN 3BS5
Enriched GO Terms of Interacting Partners?
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