NQO1 and GALT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NQO1	GALT
Description		NAD(P)H quinone dehydrogenase 1	galactose-1-phosphate uridylyltransferase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Neuronal Cell Body Synapse	Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Identical Protein Binding NADH Dehydrogenase (quinone) Activity	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding
	Biological Process	Response To Ischemia NADH Oxidation Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Response To Amine Removal Of Superoxide Radicals Response To Estradiol Response To Testosterone Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Response To Ethanol Response To Electrical Stimulus Cellular Response To Hydrogen Peroxide NADPH Oxidation Cellular Response To Metal Ion Response To Tetrachloromethane Response To L-glutamine Response To Hydrogen Sulfide Response To Flavonoid	UDP-glucose Metabolic Process Galactose Metabolic Process UDP-glucose Catabolic Process Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose
Pathways		Regulation of ornithine decarboxylase (ODC)	Defective GALT can cause Galactosemia Galactose catabolism
Drugs		Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: CDC42 CDH16 CDH5 DNAJB1 GALT HIF1A HSPA1A ING1 PRKN STUB1 TP53 UBE2D1	9 interacting genes: CCL19 CCL21 GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 UBTD2 VAC14
Entrez ID		1728	2592
HPRD ID		00518	06106
Ensembl ID		ENSG00000181019	ENSG00000213930
Uniprot IDs		B4DLR8 P15559	A0A0S2Z3Y7 B2RAT6 P07902
PDB IDs		1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4 6LLC	1R3A 5IN3 6GQD
Enriched GO Terms of Interacting Partners?
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