OIT3 and ANAPC16

		OIT3	ANAPC16
Description		oncoprotein induced transcript 3	anaphase promoting complex subunit 16
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nuclear Envelope Cell Surface	Kinetochore Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Urate Homeostasis	Cell Cycle Protein Ubiquitination Cell Division
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Low density lipoprotein cholesterol levels ( 29403010 33339817) Refractive error ( 32231278) Total cholesterol levels ( 29403010 33339817)	Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		15 interacting genes: ANAPC16 CRCT1 ESYT1 FBXO34 HOXA1 KRTAP11-1 LCE1C LCE1F LCE3A MEOX2 PLA2G12B TBATA TYSND1 UNC5B VAC14	3 interacting genes: HSF2BP OIT3 RBBP6
Entrez ID		170392	119504
HPRD ID		17660	12554
Ensembl ID		ENSG00000138315	ENSG00000166295
Uniprot IDs		Q8WWZ8	A0A087WUN5 C5H3H2 Q96DE5
PDB IDs			4RG6 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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