DEFA5 and DTX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DEFA5	DTX1
Description		defensin alpha 5	deltex E3 ubiquitin ligase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Transport Vesicle Midbody Secretory Granule Lumen Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Protein Binding Protein Homodimerization Activity	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Innate Immune Response In Mucosa Antibacterial Humoral Response Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Positive Regulation Of Membrane Permeability	Transcription, DNA-templated Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor
Pathways		Defensins Alpha-defensins	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 30072576) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Mercury levels ( 26025379)	Body mass index ( 26426971) Coffee consumption ( 29367735) Retinitis pigmentosa ( 33514863) Visceral adipose tissue adjusted for BMI ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: ACE2 DTX1 MEOX2 PRSS1	21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U
Entrez ID		1670	1840
HPRD ID		02720	03991
Ensembl ID		ENSG00000164816	ENSG00000135144
Uniprot IDs		Q01523	Q86Y01
PDB IDs		1ZMP 2LXZ 2MIT 3I5W 4E82 4E83 4E86 4RBW 4RBX 5CUI 5CUJ 5CUM	6Y5N 6Y5P
Enriched GO Terms of Interacting Partners?
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