DDX10 and CUL5

		DDX10	CUL5
Description		DEAD-box helicase 10	cullin 5
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GO Annotations	Cellular Component	Nucleus	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding ATP Hydrolysis Activity	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	RRNA Processing Anterior Head Development	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways			Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)	Refractive error ( 32231278)
Interacting Genes		16 interacting genes: ANTXR2 APP ARHGAP20 ARL2BP BCO2 CUL5 DES DSC3 FBXO7 HSPB2 IGFBP6 NPAT PGR PTS SIRPA SLN	38 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		1662	8065
HPRD ID		03138	03444
Ensembl ID		ENSG00000178105	ENSG00000166266
Uniprot IDs		Q13206	Q93034
PDB IDs		2PL3	3DPL 3DQV 4JGH 4N9F 6V9I
Enriched GO Terms of Interacting Partners?
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