DHX9 and HDLBP

Number of citations of the paper that reports this interaction (PubMedID 15723802)
37

Data Source:
HPRD (in vitro)

		DHX9	HDLBP
Description		DExH-box helicase 9	high density lipoprotein binding protein
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Polysome Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane High-density Lipoprotein Particle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Nucleoside-triphosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding RNA Polymerase Binding RISC Complex Binding Polysome Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding	RNA Binding MRNA Binding Protein Binding Lipid Binding Cadherin Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Osteoblast Differentiation DNA Replication DNA-templated Transcription, Termination Regulation Of Transcription By RNA Polymerase II Inflammatory Response RNA Secondary Structure Unwinding Targeting Of MRNA For Destruction Involved In RNA Interference DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Protein-containing Complex Assembly DNA-templated Viral Transcription G-quadruplex DNA Unwinding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Pyroptosis Small RNA Loading Onto RISC CRD-mediated MRNA Stabilization Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Viral Translation Positive Regulation Of Polysome Binding Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Gene Silencing By MiRNA Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation	Lipid Transport Cholesterol Metabolic Process
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway	HDL clearance
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Fibrinogen levels ( 28107422 26561523) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		46 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 DUX4 EIF2AK2 ESR1 GEMIN2 GEMIN4 GTF2B H2AX HDLBP HNRNPC HNRNPK IL7R ILF3 JAK1 JUN KHDRBS1 LINC01554 MBD2 NXF1 OGA OGT PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A TYK2 UBE2I YWHAQ	14 interacting genes: ADAR CDC42 CSNK2A1 DHX9 ERBB2 ESR1 HMGB1 HMGB2 HSPB1 SMAD4 SOS1 SUMO2 TENT5A XPOT
Entrez ID		1660	3069
HPRD ID		04386	00813
Ensembl ID		ENSG00000135829	ENSG00000115677
Uniprot IDs		B3KU66 Q08211	A0A024R4E5 B2R5V9 Q00341
PDB IDs		3LLM 3VYX 3VYY	1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?
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