DDX1 and MIR29B1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		DDX1	MIR29B1
Description		DEAD-box helicase 1	microRNA 29b-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Membrane Cleavage Body TRNA-splicing Ligase Complex Ribonucleoprotein Complex	Extracellular Space Nucleus Cytoplasm Mitochondrion Extracellular Exosome Extracellular Vesicle
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Nuclease Activity Exonuclease Activity Protein Binding ATP Binding Poly(A) Binding ATP Hydrolysis Activity DNA/RNA Helicase Activity	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Spliceosomal Complex Assembly Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Double-strand Break Repair Regulation Of Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Translational Initiation Multicellular Organism Development DNA Duplex Unwinding Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Defense Response To Virus Nucleic Acid Phosphodiester Bond Hydrolysis Protein Localization To Cytoplasmic Stress Granule	Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Type III Interferon Production Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of DNA Methylation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Negative Regulation Of Protein Kinase B Signaling Regulation Of Membrane Repolarization Regulation Of Blood Vessel Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Virus Negative Regulation Of Interleukin-32 Production Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Mesenchymal Stem Cell Proliferation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Aorta Morphogenesis Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Metalloendopeptidase Activity Regulation Of Epithelium Regeneration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Negative Regulation Of Intestinal Epithelial Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		tRNA processing in the nucleus
Drugs
Diseases
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 22479191) Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney volume ( 34128465) Metabolite levels ( 23823483) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Urate levels ( 31578528) Wilms tumor ( 22544364)	Pancreatic cancer ( 25086665) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		83 interacting genes: APP ATM CSTF2 ESR1 HNRNPK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NDRG1 NME7 PTEN RELA SUMO2 YWHAQ	72 interacting genes: APOBEC3B C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA RBFOX2 RBM14 RBM4 RBM47 RBMS2 RTCB SF3B1 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		1653	407024
HPRD ID		03158
Ensembl ID		ENSG00000079785	ENSG00000283797
Uniprot IDs		A3RJH1 Q92499
PDB IDs		4XW3
Enriched GO Terms of Interacting Partners?
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