DDB1 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 24360965)
27

Data Source:
BioGRID (pull down)

		DDB1	H1-2
Description		damage specific DNA binding protein 1	H1.2 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Histone H2A Monoubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Biological Process Involved In Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Interacting Genes		47 interacting genes: ABL1 BRAP CCNK CDK12 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 GPS1 GSPT1 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MUS81 PIN1 PTEN RASSF1 SALL2 SHANK3 SIN3A SIRT7 SKP2 STAT1 SUPT3H SUV39H1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZNF277	29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1
Entrez ID		1642	3006
HPRD ID		10952	07514
Ensembl ID		ENSG00000167986	ENSG00000187837
Uniprot IDs		Q16531	P16403
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9
Enriched GO Terms of Interacting Partners?
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