SPPL2C and RETREG3

		SPPL2C	RETREG3
Description		signal peptide peptidase like 2C	reticulophagy regulator family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi-associated Vesicle Membrane Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity	Protein Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis	Positive Regulation Of Neuron Projection Development Reticulophagy
Pathways
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561 33909500) Hand grip strength ( 29691431) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic pulmonary fibrosis ( 24429156) Male-pattern baldness ( 28196072) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Red blood cell count ( 27863252) Waist-hip index ( 34021172)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		4 interacting genes: CYSRT1 NBPF19 NOTCH2NLA RETREG3	113 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARHGAP27 ARL6IP1 ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 C4orf3 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 IFITM3 JAGN1 KANSL1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 REEP6 RUNDC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 SPPL2C STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6
Entrez ID		162540	162427
HPRD ID		07085	14108
Ensembl ID		ENSG00000185294	ENSG00000141699
Uniprot IDs		Q8IUH8	K7EQI9 Q86VR2
PDB IDs
Enriched GO Terms of Interacting Partners?
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