USP51 and H2BC3

Number of citations of the paper that reports this interaction (PubMedID 30192049)
6

Data Source:
BioGRID (enzymatic study)

		USP51	H2BC3
Description		ubiquitin specific peptidase 51	H2B clustered histone 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Cytosol
	Molecular Function	Chromatin Binding Thiol-dependent Deubiquitinase Zinc Ion Binding Histone Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deubiquitination Protein Deubiquitination Regulation Of Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation
Drugs
Diseases
GWAS		Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		9 interacting genes: CDK4 CDK6 H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28	29 interacting genes: AKT1 ANAPC11 APP CDK1 CDK2 CHD4 CREBBP DNMT1 DYRK1A EID1 EP300 ERCC6 FANCD2 H2AC4 KAT2B MYB PALB2 PSMD4 RHBDD2 RNF20 RNF8 RPS6KA5 UBR7 UHRF1 USP16 USP36 USP43 USP51 USP7
Entrez ID		158880	3018
HPRD ID		07167	07536
Ensembl ID		ENSG00000247746	ENSG00000276410
Uniprot IDs		Q70EK9	P33778
PDB IDs			3X1S 3X1U
Enriched GO Terms of Interacting Partners?
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