CYP3A4 and UGT2B7

Number of citations of the paper that reports this interaction (PubMedID 15611481)
11

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		CYP3A4	UGT2B7
Description		cytochrome P450 family 3 subfamily A member 4	UDP glucuronosyltransferase family 2 member B7
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Steroid Binding Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Caffeine Oxidase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity 1,8-cineole 2-exo-monooxygenase Activity	Retinoic Acid Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity
	Biological Process	Lipid Hydroxylation Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Calcitriol Biosynthetic Process From Calciol Xenobiotic Catabolic Process Vitamin D Metabolic Process Vitamin D Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Aflatoxin Metabolic Process Heterocycle Metabolic Process Oxidative Demethylation	Lipid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Cellular Glucuronidation
Pathways		Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs	Glucuronidation
Drugs		Glutathione Isoniazid Pradefovir mesylate Casopitant Diacerein
Diseases
GWAS		Metabolic traits ( 21886157) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Pre-treatment viral load in HIV-1 infection ( 31219150) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)	AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Estradiol levels ( 34255042) Gamma glutamyl transferase levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7	2 interacting genes: CYP3A4 GABRA3
Entrez ID		1576	7364
HPRD ID		00484	02508
Ensembl ID		ENSG00000160868	ENSG00000171234
Uniprot IDs		P08684 Q6GRK0	E9PBP8 P16662
PDB IDs		1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB 7KVH 7KVI 7KVJ 7KVK 7KVM 7KVN 7KVO 7KVP 7KVQ 7KVS	2O6L
Enriched GO Terms of Interacting Partners?
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