CYP2E1 and ABCA5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CYP2E1	ABCA5
Description		cytochrome P450 family 2 subfamily E member 1	ATP binding cassette subfamily A member 5
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Hsp90 Protein Binding Aromatase Activity	Lipid Transporter Activity ATP Binding ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Lipid Hydroxylation Organic Acid Metabolic Process Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process Response To Ethanol Heterocycle Metabolic Process	Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Cholesterol Efflux High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Transmembrane Transport Positive Regulation Of Reverse Cholesterol Transport
Pathways		Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs	ABC transporters in lipid homeostasis
Drugs		Diacerein
Diseases
GWAS		Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Blood protein levels ( 29875488) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Iron status biomarkers (iron levels) ( 33536631) Metabolite levels ( 23823483) Normal facial asymmetry (deformation magnitude) ( 30631343)
Interacting Genes		15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1	2 interacting genes: CYP2E1 NR4A1
Entrez ID		1571	23461
HPRD ID		11813	09789
Ensembl ID		ENSG00000130649	ENSG00000154265
Uniprot IDs		P05181	Q8WWZ7
PDB IDs		3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?
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