METTL27 and FOXC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		METTL27	FOXC2
Description		methyltransferase like 27	forkhead box C2
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding Methyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Ossification Branching Involved In Blood Vessel Morphogenesis Metanephros Development Ureteric Bud Development Somitogenesis Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Heart Development Insulin Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Endothelial Cell Migration Neural Crest Cell Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Embryonic Heart Tube Development Positive Regulation Of Vascular Wound Healing Camera-type Eye Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesodermal Cell Fate Commitment Embryonic Viscerocranium Morphogenesis Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Glomerular Endothelium Development Glomerular Visceral Epithelial Cell Differentiation Glomerular Mesangial Cell Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Diameter Maintenance Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
Pathways
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Nose size ( 27182965) Sepsis in extremely premature infants ( 28283553) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		29 interacting genes: A1CF ATXN1 ATXN1L CCDC120 CSTF2 DOK6 EFHC1 ENKD1 FOXC2 GLYCTK GPANK1 GRB2 HGS KDM1A LMO4 NOXA1 PITX1 PPP1R32 PRKAB2 PRMT6 PROP1 SNRPC TBX6 TEKT3 TFG TLX3 VPS37C ZIC1 ZNF77	7 interacting genes: CNOT7 GOLGA2 KRTAP3-3 METTL27 RBPMS TAX1BP1 TRIM27
Entrez ID		155368	2303
HPRD ID		15661	03869
Ensembl ID		ENSG00000165171	ENSG00000176692
Uniprot IDs		Q8N6F8	Q99958
PDB IDs			1D5V 6AKO 6AKP 6LBM 6O3T
Enriched GO Terms of Interacting Partners?
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